Target
Endothelin-1 receptor
Ligand
BDBM50101247
Substrate
n/a
Meas. Tech.
ChEBML_65627
IC50
77±n/a nM
Citation
 Kukkola, PJBilci, NAIkler, TSavage, PShetty, SSDelGrande, DJeng, AY Isoindolines: a new series of potent and selective endothelin-A receptor antagonists. Bioorg Med Chem Lett 11:1737-40 (2001) [PubMed]  Article 
Target
Name:
Endothelin-1 receptor
Synonyms:
EDNRA | EDNRA_HUMAN | ET-A | ETA | ETA-R | ETRA | Endothelin receptor type A | Endothelin receptor, ET-A/ET-B | hET-AR
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48736.88
Organism:
Homo sapiens (Human)
Description:
P25101
Residue:
427
Sequence:
METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLPSNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCMLNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRSSHKDSMN
  
Inhibitor
Name:
BDBM50101247
Synonyms:
CHEMBL49850 | [(1R,3S)-1-Benzo[1,3]dioxol-5-yl-5-ethoxy-3-(2-hydroxy-4-methoxy-phenyl)-1,3-dihydro-isoindol-2-yl]-acetic acid
Type:
Small organic molecule
Emp. Form.:
C26H25NO7
Mol. Mass.:
463.4792
SMILES:
CCOc1ccc2[C@H](N(CC(O)=O)[C@@H](c2c1)c1ccc(OC)cc1O)c1ccc2OCOc2c1
Structure:
Search PDB for entries with ligand similarity: