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Target
Glutamate carboxypeptidase 2
Ligand
BDBM50102258
Substrate
n/a
Meas. Tech.
ChEMBL_71709 (CHEMBL680923)
IC50
47±n/a nM
Citation
 Kozikowski, AP; Nan, F; Conti, P; Zhang, J; Ramadan, E; Bzdega, T; Wroblewska, B; Neale, JH; Pshenichkin, S; Wroblewski, JT Design of remarkably simple, yet potent urea-based inhibitors of glutamate carboxypeptidase II (NAALADase). J Med Chem 44:298-301 (2001) [PubMed]  Article 
Target
Name:
Glutamate carboxypeptidase 2
Synonyms:
FOLH1_RAT | Folh1 | Glutamate carboxypeptidase II | Naalad1
Type:
PROTEIN
Mol. Mass.:
84547.28
Organism:
Rattus norvegicus
Description:
ChEMBL_68365
Residue:
752
Sequence:
MWNAQQDSDSAEALGRRQRWFCAGTLVLAFTGTFIIGFLFGWFIKPSNDSTSSVSYPGMKKAFLQELKAENIKKFLYNFTRTPHLAGTQHNFELAKQIHAQWKEFGLDLVELSDYDVLLSYPNKTHPNYISIINEDGNEIFKTSLAELSPPGYENISDVVPPYSAFSPQGTPEGDLVYVNYARTEDFFKLERVMKINCSGKIVIARYGQVFRGNKVKNAQLAGAKGIILYSDPADYFVPGVKSYPDGWNLPGGGVQRGNVLNLNGAGDPLTPGYPANEYAYRHEFTEAVGLPSIPVHPIGYDDAQKLLEHMGGSAPPDSSWKGGLKVPYNVGPGFAGNFSKQKVKLHIHSYNKVTRIYNVIGTLKGAVEPDRYVILGGHRDAWVFGGIDPQSGAAVVHEIVRTFGTLKKKGWRPRRTILFASWDAEEFGLLGSTEWAEEHSRLLQERGVAYINADSSIEGNYTLRVDCTPLMHSLVYNLTKELPSPDEGFEGKSLYDSWKEKSPSTEFIGMPRISKLGSGNDFEVFFQRLGIASGRARYTKNWKNNKVSSYPLYHSVYETYELVEKFYDPTFKYHLTVAQVRGAMVFELANSIVLPFDCQSYAVALKKHAETIYNISMNHPQEMKAYMISFDSLFSAVNNFTDVASKFNQRLQDLDKSNPILLRILNDQLMYLERAFIDPLGLPGRPFYRHIIYAPSSHNKYAGESFPGIYDALFDINNKVDTSKAWREVKRQISIAAFTVQAAAETLREVD
  
Inhibitor
Name:
BDBM50102258
Synonyms:
(S)-2-[3-((S)-3-Carboxy-1-carboxy-propyl)-ureido]-pentanedioic acid | 2-[3-(1,3-Dicarboxy-propyl)-ureido]-pentanedioic acid | CHEMBL46005
Type:
Small organic molecule
Emp. Form.:
C11H16N2O9
Mol. Mass.:
320.2527
SMILES:
OC(=O)CC[C@H](NC(=O)N[C@@H](CCC(O)=O)C(O)=O)C(O)=O
Structure:
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