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Target
D(2) dopamine receptor
Ligand
BDBM50102318
Substrate
n/a
Meas. Tech.
ChEMBL_61606 (CHEMBL675928)
IC50
132±n/a nM
Citation
 Warawa, EJ; Migler, BM; Ohnmacht, CJ; Needles, AL; Gatos, GC; McLaren, FM; Nelson, CL; Kirkland, KM Behavioral approach to nondyskinetic dopamine antagonists: identification of seroquel. J Med Chem 44:372-89 (2001) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2_RAT | Dopamine D2 receptor | Dopamine2-like | Drd2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
50931.60
Organism:
Rattus norvegicus (rat)
Description:
P61169
Residue:
444
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
  
Inhibitor
Name:
BDBM50102318
Synonyms:
2-{2-[4-(5,5-Dioxo-5H-5lambda*6*-dibenzo[b,f][1,4]thiazepin-11-yl)-piperazin-1-yl]-ethoxy}-ethanol | CHEMBL126526
Type:
Small organic molecule
Emp. Form.:
C21H25N3O4S
Mol. Mass.:
415.506
SMILES:
OCCOCCN1CCN(CC1)C1=Nc2ccccc2S(=O)(=O)c2ccccc12 |t:13|
Structure:
Search PDB for entries with ligand similarity: