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Target
Muscarinic acetylcholine receptor M2
Ligand
BDBM50103770
Substrate
n/a
Meas. Tech.
ChEMBL_139752 (CHEMBL745193)
Ki
1.2±n/a nM
Citation
 Boyle, CD; Chackalamannil, S; Clader, JW; Greenlee, WJ; Josien, HB; Kaminski, JJ; Kozlowski, JA; McCombie, SW; Nazareno, DV; Tagat, JR; Wang, Y; Zhou, G; Billard, W; Binch, H; Crosby, G; Cohen-Williams, M; Coffin, VL; Cox, KA; Grotz, DE; Duffy, RA; Ruperto, V; Lachowicz, JE Metabolic stabilization of benzylidene ketal M(2) muscarinic receptor antagonists via halonaphthoic acid substitution. Bioorg Med Chem Lett 11:2311-4 (2001) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M2
Synonyms:
ACM2_HUMAN | CHRM2 | Cholinergic, muscarinic M2 | Muscarinic acetylcholine receptor M2 and M4 | Muscarinic acetylcholine receptor M2 and M5 | RecName: Full=Muscarinic acetylcholine receptor M2
Type:
GPCR
Mol. Mass.:
51730.61
Organism:
Homo sapiens (Human)
Description:
P08172
Residue:
466
Sequence:
MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
  
Inhibitor
Name:
BDBM50103770
Synonyms:
(7-Fluoro-naphthalen-1-yl)-(4-{2-[4-(4-methoxy-benzenesulfonyl)-phenyl]-[1,3]dioxolan-2-yl}-[1,4']bipiperidinyl-1'-yl)-methanone | CHEMBL308166
Type:
Small organic molecule
Emp. Form.:
C37H39FN2O6S
Mol. Mass.:
658.779
SMILES:
COc1ccc(cc1)S(=O)(=O)c1ccc(cc1)C1(OCCO1)C1CCN(CC1)C1CCN(CC1)C(=O)c1cccc2ccc(F)cc12
Structure:
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