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Target
M-phase inducer phosphatase 2
Ligand
BDBM50104685
Substrate
n/a
Meas. Tech.
ChEMBL_49038 (CHEMBL662076)
IC50
>125000±n/a nM
Citation
 Sodeoka, M; Sampe, R; Kojima, S; Baba, Y; Usui, T; Ueda, K; Osada, H Synthesis of a tetronic acid library focused on inhibitors of tyrosine and dual-specificity protein phosphatases and its evaluation regarding VHR and cdc25B inhibition. J Med Chem 44:3216-22 (2001) [PubMed]  Article 
Target
Name:
M-phase inducer phosphatase 2
Synonyms:
Cdc25b | Cdc25m2 | Dual specificity phosphatase Cdc25B | M-phase inducer phosphatase 2 | MPIP2_MOUSE
Type:
PROTEIN
Mol. Mass.:
65485.87
Organism:
Mus musculus
Description:
ChEMBL_49038
Residue:
576
Sequence:
MEVPLQKSAPGSALSPARVLGGIQRPRHLSVFEFESDGFLGSPEPTASSSPVTTLTQTMHNLAGLGSEPPKAQVGSLSFQNRLADLSLSRRTSECSLSSESSESSDAGLCMDSPSPVDPQMAERTFEQAIQAASRVIQNEQFTIKRFRSLPVRLLEHSPVLQSITNSRALDSWRKTEAGYRAAANSPGEDKENDGYIFKMPQELPHSSSAQALAEWVSRRQAFTQRPSSAPDLMCLTTEWKMEVEELSPVAQSSSLTPVERASEEDDGFVDILESDLKDDEKVPAGMENLISAPLVKKLDKEEEQDLIMFSKCQRLFRSPSMPCSVIRPILKRLERPQDRDVPVQSKRRKSVTPLEEQQLEEPKARVFRSKSLCHEIENILDSDHRGLIGDYSKAFLLQTVDGKHQDLKYISPETMVALLTGKFSNIVEKFVIVDCRYPYEYEGGHIKNAVNLPLERDAETFLLQRPIMPCSLDKRIILIFHCEFSSERGPRMCRFIRERDRAANDYPSLYYPEMYILKGGYKEFFPQHPNFCEPQDYRPMNHEAFRDELRNFRLKTRSWAGERSRRELCSRLQDQ
  
Inhibitor
Name:
BDBM50104685
Synonyms:
4-Hydroxy-5-hydroxymethyl-2-oxo-2,5-dihydro-furan-3-carboxylic acid benzyl ester | CHEMBL109577
Type:
Small organic molecule
Emp. Form.:
C13H12O6
Mol. Mass.:
264.2308
SMILES:
OCc1oc(O)c(C(=O)OCc2ccccc2)c1O
Structure:
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