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Target
Retinoid isomerohydrolase
Ligand
BDBM323415
Substrate
n/a
Meas. Tech.
ChEMBL_2015623 (CHEMBL4669201)
EC50
172±n/a nM
Citation
 Blum, E; Zhang, J; Korshin, E; Palczewski, K; Gruzman, A Development of chiral fluorinated alkyl derivatives of emixustat as drug candidates for the treatment of retinal degenerative diseases. Bioorg Med Chem Lett 30:0 (2020) [PubMed]  Article 
Target
Name:
Retinoid isomerohydrolase
Synonyms:
Lutein isomerase | Meso-zeaxanthin isomerase | RPE65 | RPE65_BOVIN | Retinal pigment epithelium-specific 65 kDa protein | Retinoid isomerohydrolase
Type:
Enzyme Catalytic Domain
Mol. Mass.:
60942.63
Organism:
Bos taurus (Bovine)
Description:
Q28175
Residue:
533
Sequence:
MSSQVEHPAGGYKKLFETVEELSSPLTAHVTGRIPLWLTGSLLRCGPGLFEVGSEPFYHLFDGQALLHKFDFKEGHVTYHRRFIRTDAYVRAMTEKRIVITEFGTCAFPDPCKNIFSRFFSYFRGVEVTDNALVNIYPVGEDYYACTETNFITKVNPETLETIKQVDLCNYVSVNGATAHPHIENDGTVYNIGNCFGKNFSIAYNIVKIPPLQADKEDPISKSEIVVQFPCSDRFKPSYVHSFGLTPNYIVFVETPVKINLFKFLSSWSLWGANYMDCFESNETMGVWLHIADKKRKKYINNKYRTSPFNLFHHINTYEDHEFLIVDLCCWKGFEFVYNYLYLANLRENWEEVKKNARKAPQPEVRRYVLPLNIDKADTGKNLVTLPNTTATAILCSDETIWLEPEVLFSGPRQAFEFPQINYQKYGGKPYTYAYGLGLNHFVPDRLCKLNVKTKETWVWQEPDSYPSEPIFVSHPDALEEDDGVVLSVVVSPGAGQKPAYLLILNAKDLSEVARAEVEINIPVTFHGLFKKS
  
Inhibitor
Name:
BDBM323415
Synonyms:
3-Amino-1-(3-(cyclohexylmethoxy)Phenyl)Propan-1-Ol | US10188615, Example 4 | US10639286, Example 4
Type:
Small organic molecule
Emp. Form.:
C16H25NO2
Mol. Mass.:
263.3752
SMILES:
NCCC(O)c1cccc(OCC2CCCCC2)c1
Structure:
Search PDB for entries with ligand similarity: