Reaction Details Report a problem with these data
Target
Histone deacetylase 1
Ligand
BDBM50105677
Substrate
n/a
Meas. Tech.
ChEMBL_205835 (CHEMBL810946)
EC50
10000±n/a nM
Citation
Lavoie, R; Bouchain, G; Frechette, S; Woo, SH; Abou-Khalil, E; Leit, S; Fournel, M; Yan, PT; Trachy-Bourget, MC; Beaulieu, C; Li, Z; Besterman, J; Delorme, D Design and synthesis of a novel class of histone deacetylase inhibitors. Bioorg Med Chem Lett 11:2847-50 (2001) [PubMed] Article
More Info.:
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
Inhibitor
Name:
BDBM50105677
Synonyms:
(E)-N-Hydroxy-3-[4-(toluene-4-sulfonylamino)-phenyl]-acrylamide | CHEMBL317570 | N-Hydroxy-3-[4-(toluene-4-sulfonylamino)-phenyl]-acrylamide | N-hydroxy-3-(4-(4-methylphenylsulfonamido)phenyl)acrylamide | US8796330, 108
Type:
Small organic molecule
Emp. Form.:
C16H16N2O4S
Mol. Mass.:
332.374
SMILES:
Cc1ccc(cc1)S(=O)(=O)Nc1ccc(\C=C\C(=O)NO)cc1