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Target
Histone deacetylase 1
Ligand
BDBM50105683
Substrate
n/a
Meas. Tech.
ChEMBL_205835 (CHEMBL810946)
EC50
2000±n/a nM
Citation
 Lavoie, R; Bouchain, G; Frechette, S; Woo, SH; Abou-Khalil, E; Leit, S; Fournel, M; Yan, PT; Trachy-Bourget, MC; Beaulieu, C; Li, Z; Besterman, J; Delorme, D Design and synthesis of a novel class of histone deacetylase inhibitors. Bioorg Med Chem Lett 11:2847-50 (2001) [PubMed]  Article 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM50105683
Synonyms:
(E)-N-Hydroxy-3-[4-(4-trifluoromethoxy-benzenesulfonylamino)-phenyl]-acrylamide | CHEMBL97384 | N-hydroxy-3-(4-(4-(trifluoromethoxy)phenylsulfonamido)phenyl)acrylamide | US8796330, 112
Type:
Small organic molecule
Emp. Form.:
C16H13F3N2O5S
Mol. Mass.:
402.345
SMILES:
ONC(=O)\C=C\c1ccc(NS(=O)(=O)c2ccc(OC(F)(F)F)cc2)cc1
Structure:
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