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Target
Thrombopoietin receptor
Ligand
BDBM50105941
Substrate
n/a
Meas. Tech.
ChEMBL_207477 (CHEMBL815867)
EC50
2000±n/a nM
Citation
 Duffy, KJ; Darcy, MG; Delorme, E; Dillon, SB; Eppley, DF; Erickson-Miller, C; Giampa, L; Hopson, CB; Huang, Y; Keenan, RM; Lamb, P; Leong, L; Liu, N; Miller, SG; Price, AT; Rosen, J; Shah, R; Shaw, TN; Smith, H; Stark, KC; Tian, SS; Tyree, C; Wiggall, KJ; Zhang, L; Luengo, JI Hydrazinonaphthalene and azonaphthalene thrombopoietin mimics are nonpeptidyl promoters of megakaryocytopoiesis. J Med Chem 44:3730-45 (2001) [PubMed]  Article 
Target
Name:
Thrombopoietin receptor
Synonyms:
C-mpl | CD_antigen=CD110 | MPL | Myeloproliferative leukemia protein | TPO-R | TPOR | TPOR_HUMAN
Type:
PROTEIN
Mol. Mass.:
71243.48
Organism:
Homo sapiens (Human)
Description:
ChEMBL_535587
Residue:
635
Sequence:
MPSWALFMVTSCLLLAPQNLAQVSSQDVSLLASDSEPLKCFSRTFEDLTCFWDEEEAAPSGTYQLLYAYPREKPRACPLSSQSMPHFGTRYVCQFPDQEEVRLFFPLHLWVKNVFLNQTRTQRVLFVDSVGLPAPPSIIKAMGGSQPGELQISWEEPAPEISDFLRYELRYGPRDPKNSTGPTVIQLIATETCCPALQRPHSASALDQSPCAQPTMPWQDGPKQTSPSREASALTAEGGSCLISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDLPGDAVALGLQCFTLDLKNVTCQWQQQDHASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQFSRCHFKSRNDSIIHILVEVTTAPGTVHSYLGSPFWIHQAVRLPTPNLHWREISSGHLELEWQHPSSWAAQETCYQLRYTGEGHQDWKVLEPPLGARGGTLELRPRSRYRLQLRARLNGPTYQGPWSSWSDPTRVETATETAWISLVTALHLVLGLSAVLGLLLLRWQFPAHYRRLRHALWPSLPDLHRVLGQYLRDTAALSPPKATVSDTCEEVEPSLLEILPKSSERTPLPLCSSQAQMDYRRLQPSCLGTMPLSVCPPMAESGSCCTTHIANHSYLPLSYWQQP
  
Inhibitor
Name:
BDBM50105941
Synonyms:
4-(2,3-Dihydroxy-naphthalen-1-ylazo)-3-hydroxy-naphthalene-1-sulfonic acid | CHEMBL122504
Type:
Small organic molecule
Emp. Form.:
C20H14N2O6S
Mol. Mass.:
410.4
SMILES:
Oc1cc(c2ccccc2c1N=Nc1c(O)c(O)cc2ccccc12)S(O)(=O)=O |w:12.14|
Structure:
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