Reaction Details Report a problem with these data
Target
Cathepsin B
Ligand
BDBM50107621
Substrate
n/a
Meas. Tech.
ChEMBL_47411 (CHEMBL657288)
IC50
30.7±n/a nM
Citation
Greenspan, PD; Clark, KL; Tommasi, RA; Cowen, SD; McQuire, LW; Farley, DL; van Duzer, JH; Goldberg, RL; Zhou, H; Du, Z; Fitt, JJ; Coppa, DE; Fang, Z; Macchia, W; Zhu, L; Capparelli, MP; Goldstein, R; Wigg, AM; Doughty, JR; Bohacek, RS; Knap, AK Identification of dipeptidyl nitriles as potent and selective inhibitors of cathepsin B through structure-based drug design. J Med Chem 44:4524-34 (2001) [PubMed] Article
More Info.:
Target
Name:
Cathepsin B
Synonyms:
APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1
Type:
Enzyme
Mol. Mass.:
37819.69
Organism:
Homo sapiens (Human)
Description:
gi_63102437
Residue:
339
Sequence:
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
Inhibitor
Name:
BDBM50107621
Synonyms:
4-[2-Cyano-2-(2-diphenylacetylamino-3-m-tolyl-propionylamino)-ethoxymethyl]-benzoic acid | CHEMBL336458
Type:
Small organic molecule
Emp. Form.:
C35H33N3O5
Mol. Mass.:
575.6536
SMILES:
Cc1cccc(C[C@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)N[C@@H](COCc2ccc(cc2)C(O)=O)C#N)c1