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Target
Excitatory amino acid transporter 3
Ligand
BDBM50107947
Substrate
n/a
Meas. Tech.
ChEMBL_68330 (CHEMBL680701)
IC50
>1000000±n/a nM
Citation
 Stensbøl, TB; Uhlmann, P; Morel, S; Eriksen, BL; Felding, J; Kromann, H; Hermit, MB; Greenwood, JR; Braüner-Osborne, H; Madsen, U; Junager, F; Krogsgaard-Larsen, P; Begtrup, M; Vedsø, P Novel 1-hydroxyazole bioisosteres of glutamic acid. Synthesis, protolytic properties, and pharmacology. J Med Chem 45:19-31 (2001) [PubMed]  Article 
Target
Name:
Excitatory amino acid transporter 3
Synonyms:
EAA3_HUMAN | EAAC1 | EAAT3 | Excitatory Amino Acid EAAT3 | HEAAC1 | SLC1A1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57096.71
Organism:
Homo sapiens (Human)
Description:
Excitatory Amino Acid EAAT3 0 HUMAN::P43005
Residue:
524
Sequence:
MGKPARKGCEWKRFLKNNWVLLSTVAAVVLGITTGVLVREHSNLSTLEKFYFAFPGEILMRMLKLIILPLIISSMITGVAALDSNVSGKIGLRAVVYYFCTTLIAVILGIVLVVSIKPGVTQKVGEIARTGSTPEVSTVDAMLDLIRNMFPENLVQACFQQYKTKREEVKPPSDPEMNMTEESFTAVMTTAISKNKTKEYKIVGMYSDGINVLGLIVFCLVFGLVIGKMGEKGQILVDFFNALSDATMKIVQIIMCYMPLGILFLIAGKIIEVEDWEIFRKLGLYMATVLTGLAIHSIVILPLIYFIVVRKNPFRFAMGMAQALLTALMISSSSATLPVTFRCAEENNQVDKRITRFVLPVGATINMDGTALYEAVAAVFIAQLNDLDLGIGQIITISITATSASIGAAGVPQAGLVTMVIVLSAVGLPAEDVTLIIAVDWLLDRFRTMVNVLGDAFGTGIVEKLSKKELEQMDVSSEVNIVNPFALESTILDNEDSDTKKSYVNGGFAVDKSDTISFTQTSQF
  
Inhibitor
Name:
BDBM50107947
Synonyms:
2-Amino-3-(1-hydroxy-5-methyl-1H-imidazol-2-yl)-propionic acid | CHEMBL104039
Type:
Small organic molecule
Emp. Form.:
C7H11N3O3
Mol. Mass.:
185.1805
SMILES:
Cc1cnc(CC(N)C(O)=O)n1O
Structure:
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