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Target
Neuropeptide Y receptor type 1
Ligand
BDBM50109186
Substrate
n/a
Meas. Tech.
ChEBML_143825
Ki
10±n/a nM
Citation
 Poindexter, GS; Bruce, MA; LeBoulluec, KL; Monkovic, I; Martin, SW; Parker, EM; Iben, LG; McGovern, RT; Ortiz, AA; Stanley, JA; Mattson, GK; Kozlowski, M; Arcuri, M; Antal-Zimanyi, I Dihydropyridine neuropeptide Y Y(1) receptor antagonists. Bioorg Med Chem Lett 12:379-82 (2002) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 1
Synonyms:
NPY-Y1 | NPY1-R | NPY1R | NPY1R_HUMAN | NPYR | NPYY1 | neuropeptide Y receptor Y1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44399.07
Organism:
Homo sapiens (Human)
Description:
NPY-Y1 NPY1R HUMAN::P25929
Residue:
384
Sequence:
MNSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVSKTSLKQASPVAFKKINNNDDNEKI
  
Inhibitor
Name:
BDBM50109186
Synonyms:
2,6-Dimethyl-4-(3-{3-[3-(4-phenyl-piperidin-1-yl)-propyl]-ureido}-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester | CHEMBL125807
Type:
Small organic molecule
Emp. Form.:
C32H40N4O5
Mol. Mass.:
560.6838
SMILES:
COC(=O)C1C(C(C(=O)OC)=C(C)N=C1C)c1cccc(NC(=O)NCCCN2CCC(CC2)c2ccccc2)c1 |c:13,t:10|
Structure:
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