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TargetPeroxisome proliferator-activated receptor alpha (PPAR alpha)
LigandBDBM50109555
Substrate/Competitorn/a
Meas. Tech.ChEMBL_220887
EC50 12400±n/a nM
Citation Sauerberg, P; Pettersson, I; Jeppesen, L; Bury, PS; Mogensen, JP; Wassermann, K; Brand, CL; Sturis, J; Wöldike, HF; Fleckner, J; Andersen, AS; Mortensen, SB; Svensson, LA; Rasmussen, HB; Lehmann, SV; Polivka, Z; Sindelar, K; Panajotova, V; Ynddal, L; Wulff, EM Novel tricyclic-alpha-alkyloxyphenylpropionic acids: dual PPARalpha/gamma agonists with hypolipidemic and antidiabetic activity. J Med Chem45:789-804 (2002) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Peroxisome proliferator-activated receptor alpha (PPAR alpha)
Name:Peroxisome proliferator-activated receptor
Synonyms:Nuclear receptor subfamily 1 group C member 1 | PPAR alpha/gamma | PPAR-alpha | Peroxisome Proliferator-Activated Receptor alpha | Peroxisome proliferator-activated receptor
Type:Enzyme
Mol. Mass.:52222.08
Organism:Homo sapiens (Human)
Description:Q07869
Residue:468
Sequence:
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSC
PGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACE
GCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSE
KAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFV
IHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANL
DLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFD
FAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDI
FLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50109555
NameBDBM50109555
Synonyms:3-{4-[3-(6H-Dibenzo[b,e]oxepin-11-ylidene)-propoxy]-phenyl}-2-ethoxy-propionic acid | CHEMBL354863
TypeSmall organic molecule
Emp. Form.C28H28O5
Mol. Mass.444.5189
SMILESCCOC(Cc1ccc(OCC\C=C2\c3ccccc3COc3ccccc23)cc1)C(O)=O
Structure
n/a