Reaction Details Report a problem with these data
Target
Amphiregulin
Ligand
BDBM50291702
Substrate
n/a
Meas. Tech.
ChEMBL_217975 (CHEMBL824094)
IC50
1470±n/a nM
Citation
Sawa, M; Tsukamoto, T; Kiyoi, T; Kurokawa, K; Nakajima, F; Nakada, Y; Yokota, K; Inoue, Y; Kondo, H; Yoshino, K New strategy for antedrug application: development of metalloproteinase inhibitors as antipsoriatic drugs. J Med Chem 45:930-6 (2002) [PubMed] Article
More Info.:
Target
Name:
Amphiregulin
Synonyms:
AREG | AREGB | AREG_HUMAN | SDGF
Type:
PROTEIN
Mol. Mass.:
27898.07
Organism:
Homo sapiens (Human)
Description:
ChEMBL_217975
Residue:
252
Sequence:
MRAPLLPPAPVVLSLLILGSGHYAAGLDLNDTYSGKREPFSGDHSADGFEVTSRSEMSSGSEISPVSEMPSSSEPSSGADYDYSEEYDNEPQIPGYIVDDSVRVEQVVKPPQNKTESENTSDKPKRKKKGGKNGKNRRNRKKKNPCNAEFQNFCIHGECKYIEHLEAVTCKCQQEYFGERCGEKSMKTHSMIDSSLSKIALAAIAAFMSAVILTAVAVITVQLRRQYVRKYEGEAEERKKLRQENGNVHAIA
Inhibitor
Name:
BDBM50291702
Synonyms:
(3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-yl)-(4-methoxy-phenyl)-phosphinic acid 2,2-difluoro-ethyl ester | (R)-((R)-3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-yl)-(4-methoxy-phenyl)-phosphinic acid 2,2-difluoro-ethyl ester | CHEMBL435462
Type:
Small organic molecule
Emp. Form.:
C19H21F2N2O5P
Mol. Mass.:
426.351
SMILES:
COc1ccc(cc1)[P@](=O)(OCC(F)F)N1Cc2ccccc2C[C@@H]1C(=O)NO