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Target
Urokinase-type plasminogen activator
Ligand
BDBM50110018
Substrate
n/a
Meas. Tech.
ChEBML_226014
Ki
12000±n/a nM
Citation
 Künzel, S; Schweinitz, A; Reissmann, S; Stürzebecher, J; Steinmetzer, T 4-amidinobenzylamine-based inhibitors of urokinase. Bioorg Med Chem Lett 12:645-8 (2002) [PubMed]  Article 
Target
Name:
Urokinase-type plasminogen activator
Synonyms:
3.4.21.73 | PLAU | U-plasminogen activator | UROK_HUMAN | Urokinase | Urokinase-type plasminogen activator (uPA) | Urokinase-type plasminogen activator chain B | Urokinase-type plasminogen activator long chain A | Urokinase-type plasminogen activator short chain A | Urokinase-type plasminogen activator/surface receptor | uPA
Type:
Enzyme
Mol. Mass.:
48528.62
Organism:
Homo sapiens (Human)
Description:
P00749
Residue:
431
Sequence:
MRALLARLLLCVLVVSDSKGSNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQHCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHNYCRNPDNRRRPWCYVQVGLKLLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTKEENGLAL
  
Inhibitor
Name:
BDBM50110018
Synonyms:
2-Amino-N-[(4-carbamimidoyl-benzylcarbamoyl)-methyl]-3-hydroxy-propionamide | CHEMBL160944
Type:
Small organic molecule
Emp. Form.:
C13H19N5O3
Mol. Mass.:
293.3217
SMILES:
N[C@H](CO)C(=O)NCC(=O)NCc1ccc(cc1)C(N)=N
Structure:
Search PDB for entries with ligand similarity: