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TargetMuscarinic acetylcholine receptor M2
LigandBDBM50110536
Substrate/Competitorn/a
Meas. Tech.ChEMBL_139767
Ki 0.160000±n/a nM
Citation Kozlowski, JAZhou, GTagat, JRLin, SIMcCombie, SWRuperto, VBDuffy, RAMcQuade, RACrosby, GTaylor, LABillard, WBinch, HLachowicz, JE Substituted 2-(R)-methyl piperazines as muscarinic M(2) selective ligands. Bioorg Med Chem Lett12:791-4 (2002) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Muscarinic acetylcholine receptor M2
Name:Muscarinic acetylcholine receptor M2 and M5
Synonyms:CHRM2 | Cholinergic, muscarinic M2 | RecName: Full=Muscarinic acetylcholine receptor M2
Type:GPCR
Mol. Mass.:51730.61
Organism:Homo sapiens (Human)
Description:P08172
Residue:466
Sequence:
MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY
FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD
RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF
FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRI
VKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDE
ITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNI
VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT
VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50110536
NameBDBM50110536
Synonyms:(4-Cyclohexyl-2-methyl-piperazin-1-yl)-[4-(4-methoxy-benzenesulfonyl)-phenyl]-acetonitrile | CHEMBL352739
TypeSmall organic molecule
Emp. Form.C26H33N3O3S
Mol. Mass.467.624
SMILESCOc1ccc(cc1)S(=O)(=O)c1ccc(cc1)C(C#N)N1CCN(C[C@H]1C)C1CCCCC1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
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