Target
Muscarinic acetylcholine receptor M2
Ligand
BDBM50111332
Substrate
n/a
Meas. Tech.
ChEBML_139766
Ki
0.900000±n/a nM
Citation
 Wang, YChackalamannil, SHu, ZMcKittrick, BAGreenlee, WRuperto, VDuffy, RALachowicz, JE Sulfide analogues as potent and selective M(2) muscarinic receptor antagonists. Bioorg Med Chem Lett 12:1087-91 (2002) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M2
Synonyms:
ACM2_HUMAN | CHRM2 | Cholinergic, muscarinic M2 | Muscarinic acetylcholine receptor M2 and M4 | Muscarinic acetylcholine receptor M2 and M5 | RecName: Full=Muscarinic acetylcholine receptor M2
Type:
GPCR
Mol. Mass.:
51730.61
Organism:
Homo sapiens (Human)
Description:
P08172
Residue:
466
Sequence:
MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
  
Inhibitor
Name:
BDBM50111332
Synonyms:
CHEMBL276239 | [4-(4-Isopropylsulfanyl-benzyl)-[1,4']bipiperidinyl-1'-yl]-naphthalen-1-yl-methanone
Type:
Small organic molecule
Emp. Form.:
C31H38N2OS
Mol. Mass.:
486.711
SMILES:
CC(C)Sc1ccc(CC2CCN(CC2)C2CCN(CC2)C(=O)c2cccc3ccccc23)cc1
Structure:
Search PDB for entries with ligand similarity: