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Target
Tubulin beta-2B chain
Ligand
BDBM50111559
Substrate
n/a
Meas. Tech.
ChEMBL_225810 (CHEMBL845250)
IC50
31000±n/a nM
Citation
 Wang, L; Woods, KW; Li, Q; Barr, KJ; McCroskey, RW; Hannick, SM; Gherke, L; Credo, RB; Hui, YH; Marsh, K; Warner, R; Lee, JY; Zielinski-Mozng, N; Frost, D; Rosenberg, SH; Sham, HL Potent, orally active heterocycle-based combretastatin A-4 analogues: synthesis, structure-activity relationship, pharmacokinetics, and in vivo antitumor activity evaluation. J Med Chem 45:1697-711 (2002) [PubMed]  Article 
Target
Name:
Tubulin beta-2B chain
Synonyms:
TBB2B_BOVIN | TUBB2B | Tubulin | Tubulin beta chain
Type:
PROTEIN
Mol. Mass.:
49932.38
Organism:
Bos taurus
Description:
ChEMBL_211651
Residue:
445
Sequence:
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEQGEFEEEEGEDEA
  
Inhibitor
Name:
BDBM50111559
Synonyms:
2-Methoxy-5-[3-methyl-5-(3,4,5-trimethoxy-phenyl)-3H-imidazol-4-yl]-phenylamine | CHEMBL46215
Type:
Small organic molecule
Emp. Form.:
C20H23N3O4
Mol. Mass.:
369.4143
SMILES:
COc1ccc(cc1N)-c1c(ncn1C)-c1cc(OC)c(OC)c(OC)c1
Structure:
Search PDB for entries with ligand similarity: