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Target
Cathepsin S
Ligand
BDBM50113673
Substrate
n/a
Meas. Tech.
ChEMBL_48669 (CHEMBL658340)
IC50
5700±n/a nM
Citation
 Altmann, E; Renaud, J; Green, J; Farley, D; Cutting, B; Jahnke, W Arylaminoethyl amides as novel non-covalent cathepsin K inhibitors. J Med Chem 45:2352-4 (2002) [PubMed]  Article 
Target
Name:
Cathepsin S
Synonyms:
CATS_HUMAN | CTSS | Cathepsin S (Cat S) | cathepsin S preproprotein
Type:
Protein
Mol. Mass.:
37507.38
Organism:
Homo sapiens (Human)
Description:
P25774
Residue:
331
Sequence:
MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVMLHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEI
  
Inhibitor
Name:
BDBM50113673
Synonyms:
4-Isopropyl-N-{1-[2-(4-methoxy-phenylamino)-ethylcarbamoyl]-3-methyl-butyl}-benzamide | CHEMBL306503
Type:
Small organic molecule
Emp. Form.:
C25H35N3O3
Mol. Mass.:
425.5637
SMILES:
COc1ccc(NCCNC(=O)[C@H](CC(C)C)NC(=O)c2ccc(cc2)C(C)C)cc1
Structure:
Search PDB for entries with ligand similarity: