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Target
Vasopressin V1a receptor
Ligand
BDBM50114037
Substrate
n/a
Meas. Tech.
ChEMBL_214412 (CHEMBL820276)
Ki
7.84±n/a nM
Citation
 Kakefuda, A; Suzuki, T; Tobe, T; Tsukada, J; Tahara, A; Sakamoto, S; Tsukamoto, S Synthesis and pharmacological evaluation of 5-(4-biphenyl)-3-methyl-4-phenyl-1,2,4-triazole derivatives as a novel class of selective antagonists for the human vasopressin V(1A) receptor. J Med Chem 45:2589-98 (2002) [PubMed]  Article 
Target
Name:
Vasopressin V1a receptor
Synonyms:
AVPR V1a | AVPR1 | AVPR1A | Antidiuretic hormone receptor 1a | V1AR_HUMAN | V1aR | VASOPRESSIN V1A | Vascular/hepatic-type arginine vasopressin receptor | Vasopressin V1 receptor | Vasopressin V1a receptor | Vasopressin receptor
Type:
Receptor
Mol. Mass.:
46820.18
Organism:
Homo sapiens (Human)
Description:
P37288
Residue:
418
Sequence:
MRLSAGPDAGPSGNSSPWWPLATGAGNTSREAEALGEGNGPPRDVRNEELAKLEIAVLAVTFAVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQMCWDITYRFRGPDWLCRVVKHLQVFGMFASAYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIAAAWVLSFVLSTPQYFVFSMIEVNNVTKARDCWATFIQPWGSRAYVTWMTGGIFVAPVVILGTCYGFICYNIWCNVRGKTASRQSKGAEQAGVAFQKGFLLAPCVSSVKSISRAKIRTVKMTFVIVTAYIVCWAPFFIIQMWSVWDPMSVWTESENPTITITALLGSLNSCCNPWIYMFFSGHLLQDCVQSFPCCQNMKEKFNKEDTDSMSRRQTFYSNNRSPTNSTGMWKDSPKSSKSIKFIPVST
  
Inhibitor
Name:
BDBM50114037
Synonyms:
4-{3-[2-(3-Biphenyl-4-yl-5-methyl-[1,2,4]triazol-4-yl)-phenoxy]-propyl}-piperidine | CHEMBL315232
Type:
Small organic molecule
Emp. Form.:
C29H32N4O
Mol. Mass.:
452.5906
SMILES:
Cc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1ccccc1OCCCC1CCNCC1 |(9.43,-1.75,;8.05,-2.43,;6.76,-1.61,;5.56,-2.57,;6.12,-4.01,;5.28,-5.3,;3.74,-5.22,;2.9,-6.51,;3.6,-7.87,;5.14,-7.96,;5.98,-6.68,;2.76,-9.17,;3.46,-10.54,;2.62,-11.83,;1.08,-11.74,;.38,-10.36,;1.22,-9.08,;7.65,-3.93,;8.66,-5.07,;8.17,-6.54,;9.2,-7.68,;10.71,-7.38,;11.18,-5.91,;10.17,-4.77,;10.64,-3.31,;12.02,-2.62,;13.3,-3.47,;14.68,-2.78,;15.96,-3.65,;17.31,-2.9,;18.63,-3.72,;18.57,-5.26,;17.22,-5.98,;15.91,-5.18,)|
Structure:
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