Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 3
Ligand
BDBM50115046
Substrate
n/a
Meas. Tech.
ChEBML_41925
IC50
11000±n/a nM
Citation
Wacker, DA; Santella, JB; Gardner, DS; Varnes, JG; Estrella, M; DeLucca, GV; Ko, SS; Tanabe, K; Watson, PS; Welch, PK; Covington, M; Stowell, NC; Wadman, EA; Davies, P; Solomon, KA; Newton, RC; Trainor, GL; Friedman, SM; Decicco, CP; Duncia, JV CCR3 antagonists: a potential new therapy for the treatment of asthma. Discovery and structure-activity relationships. Bioorg Med Chem Lett 12:1785-9 (2002) [PubMed] Article
More Info.:
Target
Name:
C-C chemokine receptor type 3
Synonyms:
C-C CKR-3 | C-C chemokine receptor type 3 (CCR3) | CC-CKR-3 | CCR-3 | CCR3 | CCR3_HUMAN | CD_antigen=CD193 | CKR3 | CMKBR3 | Eosinophil eotaxin receptor
Type:
Enzyme
Mol. Mass.:
41053.88
Organism:
Homo sapiens (Human)
Description:
P51677
Residue:
355
Sequence:
MTTSLDTVETFGTTSYYDDVGLLCEKADTRALMAQFVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYLRHFFHRHLLMHLGRYIPFLPSEKLERTSSVSPSTAEPELSIVF
Inhibitor
Name:
BDBM50115046
Synonyms:
CHEMBL50591 | Cyclohexanecarboxylic acid [(6aR,10aS)-4-(4,5,7,8,10,10a-hexahydro-6aH-pyrido[4,3-b]pyrrolo[3,2,1-hi]indol-9-yl)-butyl]-amide
Type:
Small organic molecule
Emp. Form.:
C24H35N3O
Mol. Mass.:
381.5542
SMILES:
O=C(NCCCCN1CC[C@@H]2[C@H](C1)c1cccc3CCN2c13)C1CCCCC1