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Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50116222
Substrate
n/a
Meas. Tech.
ChEBML_71597
Ki
7.5±n/a nM
Citation
 Gross, TD; Zhu, YF; Saunders, J; Wilcoxen, KM; Gao, Y; Connors, PJ; Guo, Z; Struthers, RS; Reinhart, GJ; Chen, C Design, synthesis and structure-activity relationships of novel imidazolo[1,2-a]pyrimid-5-ones as potent GnRH receptor antagonists. Bioorg Med Chem Lett 12:2185-7 (2002) [PubMed]  Article 
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR | GNRHR_HUMAN | GRHR | GnRH receptor | GnRH-R | Gonadotropin releasing hormone 1 (GnRHR1) | Gonadotropin-releasing hormone receptor | Gonadotropin-releasing hormone receptor (GnRH)
Type:
Enzyme
Mol. Mass.:
37749.45
Organism:
Homo sapiens (Human)
Description:
P30968
Residue:
328
Sequence:
MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL
  
Inhibitor
Name:
BDBM50116222
Synonyms:
2-(4-Butyrylamino-phenyl)-8-(2-fluoro-benzyl)-3-{[methyl-(2-pyridin-2-yl-ethyl)-amino]-methyl}-5-oxo-5,8-dihydro-imidazo[1,2-a]pyrimidine-6-carboxylic acid 1-ethyl-propyl ester | CHEMBL302769 | pentan-3-yl 8-(2-fluorobenzyl)-2-(4-butyramidophenyl)-3-((methyl(2-(pyridin-2-yl)ethyl)amino)methyl)-5-oxo-5,8-dihydroimidazo[1,2-a]pyrimidine-6-carboxylate
Type:
Small organic molecule
Emp. Form.:
C38H43FN6O4
Mol. Mass.:
666.7842
SMILES:
CCCC(=O)Nc1ccc(cc1)-c1nc2n(Cc3ccccc3F)cc(C(=O)OC(CC)CC)c(=O)n2c1CN(C)CCc1ccccn1
Structure:
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