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Target
Tyrosine-protein kinase Lck
Ligand
BDBM50116394
Substrate
n/a
Meas. Tech.
ChEMBL_221318 (CHEMBL841208)
IC50
2500±n/a nM
Citation
 Snow, RJ; Cardozo, MG; Morwick, TM; Busacca, CA; Dong, Y; Eckner, RJ; Jacober, S; Jakes, S; Kapadia, S; Lukas, S; Panzenbeck, M; Peet, GW; Peterson, JD; Prokopowicz, AS; Sellati, R; Tolbert, RM; Tschantz, MA; Moss, N Discovery of 2-phenylamino-imidazo[4,5-h]isoquinolin-9-ones: a new class of inhibitors of lck kinase. J Med Chem 45:3394-405 (2002) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase Lck
Synonyms:
2.7.10.2 | LCK | LCK_HUMAN | LSK | Leukocyte C-terminal Src kinase | Lymphocyte cell-specific protein-tyrosine kinase | Lymphocyte-specific protein tyrosine kinase | P56-LCK | Protein YT16 | Proto-oncogene Lck | Proto-oncogene tyrosine-protein kinase LCK | Src/Lck kinase | T cell-specific protein-tyrosine kinase
Type:
n/a
Mol. Mass.:
57987.83
Organism:
Homo sapiens (Human)
Description:
P06239
Residue:
509
Sequence:
MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP
  
Inhibitor
Name:
BDBM50116394
Synonyms:
2-(2,6-Dichloro-phenylamino)-3,6,6-trimethyl-3,6-dihydro-imidazo[4,5-h]isoquinoline-7,9-dione | CHEMBL325660
Type:
Small organic molecule
Emp. Form.:
C19H16Cl2N4O2
Mol. Mass.:
403.262
SMILES:
Cn1c(Nc2c(Cl)cccc2Cl)nc2c3C(=O)NC(=O)C(C)(C)c3ccc12
Structure:
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