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Target
5-hydroxytryptamine receptor 7
Ligand
BDBM50116964
Substrate
n/a
Meas. Tech.
ChEBML_3696
Ki
16±n/a nM
Citation
 Isaac, MB; Xin, T; O'Brien, A; St-Martin, D; Naismith, A; MacLean, N; Wilson, J; Demchyshyn, L; Tehim, A; Slassi, A 1-(Bicyclopiperazinyl)ethylindoles and 1-(homopiperazinyl)ethyl-indoles as highly selective and potent 5-HT(7) receptor ligands. Bioorg Med Chem Lett 12:2451-4 (2002) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 7
Synonyms:
5-HT-7 | 5-HT-X | 5-HT7 | 5-HT7L | 5-HT7S | 5-HT7b | 5HT7 | 5HT7R_HUMAN | HTR7 | Serotonin receptor 7
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
53573.08
Organism:
Homo sapiens (Human)
Description:
P34969
Residue:
479
Sequence:
MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD
  
Inhibitor
Name:
BDBM50116964
Synonyms:
6-Bromo-1-[2-(4-cyclopropyl-[1,4]diazepan-1-yl)-ethyl]-1H-indole | CHEMBL309523
Type:
Small organic molecule
Emp. Form.:
C18H24BrN3
Mol. Mass.:
362.307
SMILES:
Brc1ccc2ccn(CCN3CCCN(CC3)C3CC3)c2c1
Structure:
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