Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 4
Ligand
BDBM50105651
Substrate
n/a
Meas. Tech.
ChEMBL_3343 (CHEMBL619043)
Ki
719.0±n/a nM
Citation
 López-Rodríguez, ML; Murcia, M; Benhamú, B; Viso, A; Campillo, M; Pardo, L Benzimidazole derivatives. 3. 3D-QSAR/CoMFA model and computational simulation for the recognition of 5-HT(4) receptor antagonists. J Med Chem 45:4806-15 (2002) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 4
Synonyms:
5-HT-4 | 5-HT4 | 5-HT4L | 5-HT4S | 5-hydroxytryptamine receptor 4 | 5HT4R_RAT | Htr4 | Serotonin (5-HT) receptor | Serotonin 4 (5-HT4) receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
46117.31
Organism:
RAT
Description:
5-HT4 HTR4 RAT::Q62758
Residue:
406
Sequence:
MDRLDANVSSNEGFGSVEKVVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVNAFGAIELVQDIWFYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDVIEKRKFNHNSNSTFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESRPQTADQHSTHRMRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYKRPPILGQTVPCSTTTINGSTHVLRDTVECGGQWESRCHLTATSPLVAAQPVIRRPQDNDLEDSCSLKRSQS
  
Inhibitor
Name:
BDBM50105651
Synonyms:
1H-Benzoimidazole-4-carboxylic acid (1-methyl-piperidin-4-yl)-amide | CHEMBL18473
Type:
Small organic molecule
Emp. Form.:
C14H18N4O
Mol. Mass.:
258.3189
SMILES:
CN1CCC(CC1)NC(=O)c1cccc2nc[nH]c12
Structure:
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