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Target
Growth hormone secretagogue receptor type 1
Ligand
BDBM50083974
Substrate
n/a
Meas. Tech.
ChEBML_89487
Ki
7±n/a nM
Citation
 Carpino, PA; Lefker, BA; Toler, SM; Pan, LC; Hadcock, JR; Murray, MC; Cook, ER; DiBrino, JN; DeNinno, SL; Chidsey-Frink, KL; Hada, WA; Inthavongsay, J; Lewis, SK; Mangano, FM; Mullins, MA; Nickerson, DF; Ng, O; Pirie, CM; Ragan, JA; Rose, CR; Tess, DA; Wright, AS; Yu, L; Zawistoski, MP; Pettersen, JC; DaSilva-Jardine, PA; Wilson, TC; Thompson, DD Discovery and biological characterization of capromorelin analogues with extended half-lives. Bioorg Med Chem Lett 12:3279-82 (2002) [PubMed]  Article 
Target
Name:
Growth hormone secretagogue receptor type 1
Synonyms:
GH-releasing peptide receptor | GHRP | GHS-R | GHSR | GHSR_HUMAN | Ghrelin Receptor (Growth Hormone Secretagogue Receptor Type 1) | Ghrelin receptor | Ghrelin receptor 1a (GHS-R1a)
Type:
Receptor
Mol. Mass.:
41334.57
Organism:
Homo sapiens (Human)
Description:
Receptor binding studies use plasma membranes from LLC PK-1 cells transiently transfected with hGHSR1a.
Residue:
366
Sequence:
MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
  
Inhibitor
Name:
BDBM50083974
Synonyms:
2-Amino-N-[(R)-2-((R)-3a-benzyl-2-methyl-3-oxo-2,3,3a,4,6,7-hexahydro-pyrazolo[4,3-c]pyridin-5-yl)-1-benzyloxymethyl-2-oxo-ethyl]-2-methyl-propionamide | CHEMBL113313 | CP-424391-18
Type:
Small organic molecule
Emp. Form.:
C28H35N5O4
Mol. Mass.:
505.6086
SMILES:
CN1N=C2CCN(C[C@@]2(Cc2ccccc2)C1=O)C(=O)[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N |t:2|
Structure:
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