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Target
Muscarinic acetylcholine receptor M2
Ligand
BDBM50121492
Substrate
n/a
Meas. Tech.
ChEMBL_139759 (CHEMBL748895)
Ki
9.6±n/a nM
Citation
 Wang, Y; Chackalamannil, S; Hu, Z; Greenlee, WJ; Clader, J; Boyle, CD; Kaminski, JJ; Billard, W; Binch, H; Crosby, G; Ruperto, V; Duffy, RA; Cohen-Williams, M; Coffin, VL; Cox, KA; Grotz, DE; Lachowicz, JE Improving the oral efficacy of CNS drug candidates: discovery of highly orally efficacious piperidinyl piperidine M2 muscarinic receptor antagonists. J Med Chem 45:5415-8 (2002) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M2
Synonyms:
ACM2_HUMAN | CHRM2 | Cholinergic, muscarinic M2 | Muscarinic acetylcholine receptor M2 and M4 | Muscarinic acetylcholine receptor M2 and M5 | RecName: Full=Muscarinic acetylcholine receptor M2
Type:
GPCR
Mol. Mass.:
51730.61
Organism:
Homo sapiens (Human)
Description:
P08172
Residue:
466
Sequence:
MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
  
Inhibitor
Name:
BDBM50121492
Synonyms:
(4-Fluoro-naphthalen-1-yl)-(4-{1-[4-(propane-2-sulfonyl)-phenyl]-ethylidene}-[1,4']bipiperidinyl-1'-yl)-methanone | CHEMBL150845
Type:
Small organic molecule
Emp. Form.:
C32H37FN2O3S
Mol. Mass.:
548.711
SMILES:
[#6]-[#6](-[#6])S(=O)(=O)c1ccc(cc1)-[#6](\[#6])=[#6]-1/[#6]-[#6]-[#7](-[#6]-[#6]-1)-[#6]-1-[#6]-[#6]-[#7](-[#6]-[#6]-1)-[#6](=O)-c1ccc(F)c2ccccc12
Structure:
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