Reaction Details Report a problem with these data
Target
Purine nucleoside phosphorylase
Ligand
BDBM50122726
Substrate
n/a
Meas. Tech.
ChEMBL_162004 (CHEMBL764175)
Ki
0.023±n/a nM
Citation
 Evans, GB; Furneaux, RH; Gainsford, GJ; Hanson, JC; Kicska, GA; Sauve, AA; Schramm, VL; Tyler, PC 8-Aza-immucillins as transition-state analogue inhibitors of purine nucleoside phosphorylase and nucleoside hydrolases. J Med Chem 46:155-60 (2002) [PubMed]  Article 
Target
Name:
Purine nucleoside phosphorylase
Synonyms:
Inosine phosphorylase | NP | PNP | PNPH_BOVIN | Purine Nucleoside Phosphorylase (PNP) | Purine nucleoside phosphorylase
Type:
Enzyme
Mol. Mass.:
32035.18
Organism:
Bos taurus (bovine)
Description:
n/a
Residue:
289
Sequence:
MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG
  
Inhibitor
Name:
BDBM50122726
Synonyms:
2-Hydroxymethyl-5-(4-hydroxy-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-pyrrolidine-3,4-diol | CHEMBL288187
Type:
Small organic molecule
Emp. Form.:
C11H14N4O4
Mol. Mass.:
266.2533
SMILES:
OC[C@H]1NC([C@@H](O)[C@H]1O)c1c[nH]c2c1nc[nH]c2=O
Structure:
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