Reaction Details Report a problem with these data
Target
Purine nucleoside phosphorylase
Ligand
BDBM50122724
Substrate
n/a
Meas. Tech.
ChEMBL_162004 (CHEMBL764175)
Ki
0.06±n/a nM
Citation
 Evans, GB; Furneaux, RH; Gainsford, GJ; Hanson, JC; Kicska, GA; Sauve, AA; Schramm, VL; Tyler, PC 8-Aza-immucillins as transition-state analogue inhibitors of purine nucleoside phosphorylase and nucleoside hydrolases. J Med Chem 46:155-60 (2002) [PubMed]  Article 
Target
Name:
Purine nucleoside phosphorylase
Synonyms:
Inosine phosphorylase | NP | PNP | PNPH_BOVIN | Purine Nucleoside Phosphorylase (PNP) | Purine nucleoside phosphorylase
Type:
Enzyme
Mol. Mass.:
32035.18
Organism:
Bos taurus (bovine)
Description:
n/a
Residue:
289
Sequence:
MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG
  
Inhibitor
Name:
BDBM50122724
Synonyms:
4-Amino-5-(3,4-dihydroxy-5-hydroxymethyl-pyrrolidin-2-yl)-2H-pyrazole-3-carboxylic acid amide | CHEMBL41949
Type:
Small organic molecule
Emp. Form.:
C9H15N5O4
Mol. Mass.:
257.2465
SMILES:
NC(=O)c1[nH]nc(C2N[C@H](CO)[C@H](O)[C@@H]2O)c1N
Structure:
Search PDB for entries with ligand similarity: