Reaction Details Report a problem with these data
Target
Growth factor receptor-bound protein 2
Ligand
BDBM50124303
Substrate
n/a
Meas. Tech.
ChEBML_72365
IC50
>100000000±n/a nM
Citation
 Li, P; Peach, ML; Zhang, M; Liu, H; Yang, D; Nicklaus, M; Roller, PP Structure-based design of thioether-bridged cyclic phosphopeptides binding to Grb2-SH2 domain. Bioorg Med Chem Lett 13:895-9 (2003) [PubMed]  Article 
Target
Name:
Growth factor receptor-bound protein 2
Synonyms:
ASH | GRB2 | GRB2 adapter protein | GRB2_HUMAN | Grb2-SH2 | Growth factor receptor-bound protein 2
Type:
Protein
Mol. Mass.:
25205.04
Organism:
Homo sapiens (Human)
Description:
P62993
Residue:
217
Sequence:
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
  
Inhibitor
Name:
BDBM50124303
Synonyms:
3-[16-carbamoyl-31-carbamoylmethyl-10-(2-carboxyethyl)-4,19-di(4-hydroxybenzyl)-7-isobutyl-28-isopropyl-22-(2-methylsulfanylethyl)-3,6,9,12,18,21,24,27,30,33-decaoxo-14-thia-2,5,8,11,17,20,23,26,29,32-decaazacyclotritriacontanyl]propanoic acid | CHEMBL444114 | cyclo(CH2CO-Glu1-Leu2-Tyr3-Glu4-Asn5-Val6-Gly7-Met8-Tyr9-Cys10)-amide
Type:
Small organic molecule
Emp. Form.:
C55H78N12O18S2
Mol. Mass.:
1259.407
SMILES:
CSCC[C@@H]1NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)CSC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O)C(N)=O)C(C)C
Structure:
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