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Target
Histamine H3 receptor
Ligand
BDBM50127605
Substrate
n/a
Meas. Tech.
ChEMBL_83635 (CHEMBL695765)
EC50
42±n/a nM
Citation
 Kazuta, Y; Hirano, K; Natsume, K; Yamada, S; Kimura, R; Matsumoto, S; Furuichi, K; Matsuda, A; Shuto, S Cyclopropane-based conformational restriction of histamine. (1S,2S)-2-(2-aminoethyl)-1-(1H-imidazol-4-yl)cyclopropane, a highly selective agonist for the histamine H3 receptor, having a cis-cyclopropane structure. J Med Chem 46:1980-8 (2003) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48691.47
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH3R receptors.
Residue:
445
Sequence:
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK
  
Inhibitor
Name:
BDBM50127605
Synonyms:
(1S,2S)-2-(1H-Imidazol-4-yl)-cyclopropylamine | (1S,2S)-2-(3H-Imidazol-4-yl)-cyclopropylamine | 2-(1H-Imidazol-4-yl)-cyclopropylamine | CHEMBL13795 | VUF-5297
Type:
Small organic molecule
Emp. Form.:
C6H9N3
Mol. Mass.:
123.1558
SMILES:
N[C@H]1C[C@@H]1c1cnc[nH]1
Structure:
Search PDB for entries with ligand similarity: