Reaction Details Report a problem with these data
Target
ATP-sensitive inward rectifier potassium channel 11
Ligand
BDBM50127761
Substrate
n/a
Meas. Tech.
ChEBML_92724
EC50
>10000±n/a nM
Citation
 Turner, SC; Carroll, WA; White, TK; Brune, ME; Buckner, SA; Gopalakrishnan, M; Fabiyi, A; Coghlan, MJ; Scott, VE; Castle, NA; Daza, AV; Milicic, I; Sullivan, JP Structure-activity relationship of a novel class of naphthyl amide KATP channel openers. Bioorg Med Chem Lett 13:1741-4 (2003) [PubMed]  Article 
Target
Name:
ATP-sensitive inward rectifier potassium channel 11
Synonyms:
ATP-sensitive inward rectifier potassium channel 11 | IKATP | Inward rectifier K(+) channel Kir6.2 | KCJ11_HUMAN | KCNJ11 | Potassium channel, inwardly rectifying subfamily J member 11 | Potassium channel, inwardly rectifying, subfamily J, member 11 | Sulfonylurea receptor 1, Kir6.2 | Sulfonylurea receptor 2, Kir6.2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
43549.41
Organism:
Homo sapiens (Human)
Description:
Potassium channel (ATP modulatory) 0 0::Q14654
Residue:
390
Sequence:
MLSRKGIIPEEYVLTRLAEDPAEPRYRARQRRARFVSKKGNCNVAHKNIREQGRFLQDVFTTLVDLKWPHTLLIFTMSFLCSWLLFAMAWWLIAFAHGDLAPSEGTAEPCVTSIHSFSSAFLFSIEVQVTIGFGGRMVTEECPLAILILIVQNIVGLMINAIMLGCIFMKTAQAHRRAETLIFSKHAVIALRHGRLCFMLRVGDLRKSMIISATIHMQVVRKTTSPEGEVVPLHQVDIPMENGVGGNSIFLVAPLIIYHVIDANSPLYDLAPSDLHHHQDLEIIVILEGVVETTGITTQARTSYLADEILWGQRFVPIVAEEDGRYSVDYSKFGNTIKVPTPLCTARQLDEDHSLLEALTLASARGPLRKRSVPMAKAKPKFSISPDSLS
  
Inhibitor
Name:
BDBM50127761
Synonyms:
CHEMBL49390 | N-[2-(2,2,2-Trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-naphthalen-1-yl]-4-trifluoromethoxy-benzamide
Type:
Small organic molecule
Emp. Form.:
C21H12F9NO3
Mol. Mass.:
497.3105
SMILES:
OC(c1ccc2ccccc2c1NC(=O)c1ccc(OC(F)(F)F)cc1)(C(F)(F)F)C(F)(F)F
Structure:
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