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Target
Vasopressin V1a receptor
Ligand
BDBM50129463
Substrate
n/a
Meas. Tech.
ChEBML_214555
IC50
27±n/a nM
Citation
 Sum, FW; Dusza, J; Santos, ED; Grosu, G; Reich, M; Du, X; Albright, JD; Chan, P; Coupet, J; Ru, X; Mazandarani, H; Saunders, T Structure-activity study of novel tricyclic benzazepine arginine vasopressin antagonists. Bioorg Med Chem Lett 13:2195-8 (2003) [PubMed]  Article 
Target
Name:
Vasopressin V1a receptor
Synonyms:
Avpr1a | V1AR_RAT | VASOPRESSIN V1A | Vasopressin V1 receptor | Vasopressin V1a receptor | Vasopressin receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
47674.81
Organism:
RAT
Description:
VASOPRESSIN V1A AVPR1A RAT::P30560
Residue:
424
Sequence:
MSFPRGSQDRSVGNSSPWWPLTTEGSNGSQEAARLGEGDSPLGDVRNEELAKLEIAVLAVIFVVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQLCWDITYRFRGPDWLCRVVKHLQVFAMFASAYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIATSWVLSFILSTPQYFIFSVIEIEVNNGTKTQDCWATFIQPWGTRAYVTWMTSGVFVAPVVVLGTCYGFICYHIWRNIRGKTASSRHSKGDKGSGEAVGPFHKGLLVTPCVSSVKSISRAKIRTVKMTFVIVSAYILCWAPFFIVQMWSVWDENFIWTDSENPSITITALLASLNSCCNPWIYMFFSGHLLQDCVQSFPCCHSMAQKFAKDDSDSMSRRQTSYSNNRSPTNSTGMWKDSPKSSKSIRFIPVST
  
Inhibitor
Name:
BDBM50129463
Synonyms:
CHEMBL71282 | N-[4-(5H,11H-Benzo[e]pyrrolo[1,2-a][1,4]diazepine-10-carbonyl)-phenyl]-2,3-dichloro-benzamide
Type:
Small organic molecule
Emp. Form.:
C26H19Cl2N3O2
Mol. Mass.:
476.354
SMILES:
Clc1cccc(C(=O)Nc2ccc(cc2)C(=O)N2Cc3cccn3Cc3ccccc23)c1Cl
Structure:
Search PDB for entries with ligand similarity: