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Target
mRNA cap guanine-N7 methyltransferase
Ligand
BDBM50378739
Substrate
n/a
Meas. Tech.
ChEMBL_2089929 (CHEMBL4771192)
IC50
<50±n/a nM
Citation
 Ahmed-Belkacem, R; Sutto-Ortiz, P; Guiraud, M; Canard, B; Vasseur, JJ; Decroly, E; Debart, F Synthesis of adenine dinucleosides SAM analogs as specific inhibitors of SARS-CoV nsp14 RNA cap guanine-N7-methyltransferase. Eur J Med Chem 201:0 (2020) [PubMed]  Article 
Target
Name:
mRNA cap guanine-N7 methyltransferase
Synonyms:
2.1.1.56 | KIAA0398 | MCES_HUMAN | RG7MT1 | RNMT | hCMT1 | hMet | hcm1p | mRNA (guanine-N(7)-)-methyltransferase | mRNA cap guanine-N7 methyltransferase | mRNA cap methyltransferase
Type:
PROTEIN
Mol. Mass.:
54843.48
Organism:
Homo sapiens
Description:
ChEMBL_117907
Residue:
476
Sequence:
MANSAKAEEYEKMSLEQAKASVNSETESSFNINENTTASGTGLSEKTSVCRQVDIARKRKEFEDDLVKESSSCGKDTPSKKRKLDPEIVPEEKDCGDAEGNSKKRKRETEDVPKDKSSTGDGTQNKRKIALEDVPEKQKNLEEGHSSTVAAHYNELQEVGLEKRSQSRIFYLRNFNNWMKSVLIGEFLEKVRQKKKRDITVLDLGCGKGGDLLKWKKGRINKLVCTDIADVSVKQCQQRYEDMKNRRDSEYIFSAEFITADSSKELLIDKFRDPQMCFDICSCQFVCHYSFESYEQADMMLRNACERLSPGGYFIGTTPNSFELIRRLEASETESFGNEIYTVKFQKKGDYPLFGCKYDFNLEGVVDVPEFLVYFPLLNEMAKKYNMKLVYKKTFLEFYEEKIKNNENKMLLKRMQALEPYPANESSKLVSEKVDDYEHAAKYMKNSQVRLPLGTLSKSEWEATSIYLVFAFEKQQ
  
Inhibitor
Name:
BDBM50378739
Synonyms:
SINEFUNGIN | jm2c00120, Sinefungin
Type:
Small organic molecule
Emp. Form.:
C15H23N7O5
Mol. Mass.:
381.387
SMILES:
N[C@@H](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12 |r|
Structure:
Search PDB for entries with ligand similarity: