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Target
Thymidine kinase, cytosolic
Ligand
BDBM50132253
Substrate
n/a
Meas. Tech.
ChEMBL_210615 (CHEMBL815702)
IC50
>500000±n/a nM
Citation
 Hernández, AI; Balzarini, J; Rodríguez-Barrios, F; San-Félix, A; Karlsson, A; Gago, F; Camarasa, MJ; Pérez-Pérez, MJ Improving the selectivity of acyclic nucleoside analogues as inhibitors of human mitochondrial thymidine kinase: replacement of a triphenylmethoxy moiety with substituted amines and carboxamides. Bioorg Med Chem Lett 13:3027-30 (2003) [PubMed]  Article 
Target
Name:
Thymidine kinase, cytosolic
Synonyms:
KITH_HUMAN | TK1
Type:
PROTEIN
Mol. Mass.:
25476.50
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1333884
Residue:
234
Sequence:
MSCINLPTVLPGSPSKTRGQIQVILGPMFSGKSTELMRRVRRFQIAQYKCLVIKYAKDTRYSSSFCTHDRNTMEALPACLLRDVAQEALGVAVIGIDEGQFFPDIVEFCEAMANAGKTVIVAALDGTFQRKPFGAILNLVPLAESVVKLTAVCMECFREAAYTKRLGTEKEVEVIGGADKYHSVCRLCYFKKASGQPAGPDNKENCPVPGKPGEAVAARKLFAPQQILQCSPAN
  
Inhibitor
Name:
BDBM50132253
Synonyms:
5-Methyl-1-[4-(trityl-amino)-but-2-enyl]-1H-pyrimidine-2,4-dione | CHEMBL322230
Type:
Small organic molecule
Emp. Form.:
C28H27N3O2
Mol. Mass.:
437.5329
SMILES:
Cc1cn(C\C=C/CNC(c2ccccc2)(c2ccccc2)c2ccccc2)c(=O)[nH]c1=O
Structure:
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