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Target
Adenosine kinase
Ligand
BDBM50134742
Substrate
n/a
Meas. Tech.
ChEMBL_31113 (CHEMBL642224)
IC50
68±n/a nM
Citation
 Ugarkar, BG; Castellino, AJ; DaRe, JS; Ramirez-Weinhouse, M; Kopcho, JJ; Rosengren, S; Erion, MD Adenosine kinase inhibitors. 3. Synthesis, SAR, and antiinflammatory activity of a series of l-lyxofuranosyl nucleosides. J Med Chem 46:4750-60 (2003) [PubMed]  Article 
Target
Name:
Adenosine kinase
Synonyms:
ADK | ADK_HUMAN
Type:
PROTEIN
Mol. Mass.:
40545.97
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1467841
Residue:
362
Sequence:
MAAAEEEPKPKKLKVEAPQALRENILFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAEDKHKELFDELVKKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNEQPTGTCAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIAGFFLTVSPESVLKVAHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGCTFPEKPDFH
  
Inhibitor
Name:
BDBM50134742
Synonyms:
(1R,2R,3S)-2-(4-Amino-5-iodo-pyrrolo[2,3-d]pyrimidin-7-yl)-5-hydroxymethyl-tetrahydro-furan-3,4-diol | (2S,3S,4R,5R)-2-(4-Amino-5-iodo-pyrrolo[2,3-d]pyrimidin-7-yl)-5-hydroxymethyl-tetrahydro-furan-3,4-diol | CHEMBL356952
Type:
Small organic molecule
Emp. Form.:
C11H13IN4O4
Mol. Mass.:
392.1498
SMILES:
Nc1ncnc2n(cc(I)c12)[C@@H]1O[C@@H](CO)[C@@H](O)[C@H]1O
Structure:
Search PDB for entries with ligand similarity: