Reaction Details
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Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B
Ligand
BDBM50135676
Substrate
n/a
Meas. Tech.
ChEBML_161938
IC50
16000±n/a nM
Citation
Gulledge, BM; Aggen, JB; Chamberlin, AR Linearized and truncated microcystin analogues as inhibitors of protein phosphatases 1 and 2A. Bioorg Med Chem Lett 13:2903-6 (2003) [PubMed] Article More Info.:
Target
Name:
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B
Synonyms:
Serine-threonine protein phosphatase 2A regulatory subunit
Type:
PROTEIN
Mol. Mass.:
49694.81
Organism:
Gallus gallus
Description:
ChEMBL_161937
Residue:
426
Sequence:
DDDVAEADIISTVEFNHCGELLATGDKGGRVVIFQQEQENKIQSHSRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQKNAAQFLLSTNDKTIKLWKISERDKRPEGYNLKEEDGRYRDPTTVTTLRVPVFRPMDLMVEASPRRIFANAHTYHINSISINSDYETYLSADDLRINLWHLEITDRSFNIVDIKPANMEELTEVITAAEFHPNSCNTFVYSSSKGTIRLCDMRASALCDRHSKLFEEPEDPSNRSFFSEIISSISDVKFSHSGRYMMTRDYLSVKIWDLNMENRPVETYQVHEYLRSKLCSLYENDCIFDKFECCWNGSDSVVMTGSYNNFFRMFDRNTKRDITLEASRENNKPRTVLKPRKVCASGKRKKDEISVDSLDFNKKILHHAWHPKENIIAVATTNNLYIFQDKMN
Inhibitor
Name:
BDBM50135676
Synonyms:
(S)-2-[(R)-2-(2-{[(R)-4-((4E,6E)-(2S,3S,8S,9S)-3-Acetylamino-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoylamino)-4-carboxy-butyryl]-methyl-amino}-acryloylamino)-1-oxo-propylamino]-4-methyl-pentanoic acid | CHEMBL317067
Type:
Small organic molecule
Emp. Form.:
C40H59N5O10
Mol. Mass.:
769.924
SMILES:
CO[C@@H](Cc1ccccc1)[C@@H](C)\C=C(/C)\C=C\[C@H](NC(C)=O)[C@H](C)C(=O)N[C@H](CCC(=O)N(C)C(=C)C(=O)N[C@H](C)C(=O)N[C@@H](CC(C)C)C(O)=O)C(O)=O
Structure:
