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Target
Adenosine kinase
Ligand
BDBM50135904
Substrate
n/a
Meas. Tech.
ChEMBL_31115 (CHEMBL642226)
IC50
>1000±n/a nM
Citation
 Perner, RJ; Gu, YG; Lee, CH; Bayburt, EK; McKie, J; Alexander, KM; Kohlhaas, KL; Wismer, CT; Mikusa, J; Jarvis, MF; Kowaluk, EA; Bhagwat, SS 5,6,7-trisubstituted 4-aminopyrido[2,3-d]pyrimidines as novel inhibitors of adenosine kinase. J Med Chem 46:5249-57 (2003) [PubMed]  Article 
Target
Name:
Adenosine kinase
Synonyms:
ADK | ADK_HUMAN
Type:
PROTEIN
Mol. Mass.:
40545.97
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1467841
Residue:
362
Sequence:
MAAAEEEPKPKKLKVEAPQALRENILFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAEDKHKELFDELVKKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNEQPTGTCAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIAGFFLTVSPESVLKVAHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGCTFPEKPDFH
  
Inhibitor
Name:
BDBM50135904
Synonyms:
7-(4-Dimethylamino-phenyl)-5,6-bis-(4-isopropyl-phenyl)-pyrido[2,3-d]pyrimidin-4-ylamine | CHEMBL151079
Type:
Small organic molecule
Emp. Form.:
C33H35N5
Mol. Mass.:
501.6645
SMILES:
CC(C)c1ccc(cc1)-c1c(nc2ncnc(N)c2c1-c1ccc(cc1)C(C)C)-c1ccc(cc1)N(C)C
Structure:
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