Target
Disintegrin and metalloproteinase domain-containing protein 17
Ligand
BDBM50136279
Substrate
n/a
Meas. Tech.
ChEBML_212585
IC50
0.440000±n/a nM
Citation
 Xue, CBHe, XRoderick, JCorbett, RLDuan, JJLiu, RQCovington, MBQian, MRibadeneira, MDVaddi, KChrist, DDNewton, RCTrzaskos, JMMagolda, RLWexler, RRDecicco, CP Rational design, synthesis and structure-activity relationships of a cyclic succinate series of TNF-alpha converting enzyme inhibitors. Part 2: lead optimization. Bioorg Med Chem Lett 13:4299-304 (2003) [PubMed]  Article 
Target
Name:
Disintegrin and metalloproteinase domain-containing protein 17
Synonyms:
A disintegrin and metalloproteinase domain 17 | ADA17_PIG | ADAM 17 | ADAM17 | Snake venom-like protease | TACE | TNF-alpha-Converting Enzyme
Type:
Metalloprotease
Mol. Mass.:
12197.99
Organism:
Sus scrofa (pig)
Description:
Partially purified TACE was obtained from porcine spleen.
Residue:
112
Sequence:
MLREQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPIGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNE
  
Inhibitor
Name:
BDBM50136279
Synonyms:
(3R,4S)-3-Hydroxycarbamoyl-4-[4-(2-methyl-quinolin-4-ylmethoxy)-phenylcarbamoyl]-piperidine-1-carboxylic acid isopropyl ester | CHEMBL137383
Type:
Small organic molecule
Emp. Form.:
C28H32N4O6
Mol. Mass.:
520.5769
SMILES:
CC(C)OC(=O)N1CC[C@@H]([C@H](C1)C(=O)NO)C(=O)Nc1ccc(OCc2cc(C)nc3ccccc23)cc1
Structure:
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