Reaction Details Report a problem with these data
Target
Tripeptidyl-peptidase 2
Ligand
BDBM50136651
Substrate
n/a
Meas. Tech.
ChEMBL_211945 (CHEMBL816535)
IC50
135±n/a nM
Citation
 Breslin, HJ; Miskowski, TA; Kukla, MJ; De Winter, HL; Somers, MV; Roevens, PW; Kavash, RW Tripeptidyl-peptidase II (TPP II) inhibitory activity of (S)-2,3-dihydro-2-(1H-imidazol-2-yl)-1H-indoles, a systematic SAR evaluation. Part 2. Bioorg Med Chem Lett 13:4467-71 (2003) [PubMed]  Article 
Target
Name:
Tripeptidyl-peptidase 2
Synonyms:
TPP2_RAT | Tpp2 | Tripeptidyl aminopeptidase
Type:
PROTEIN
Mol. Mass.:
138287.08
Organism:
Rattus norvegicus
Description:
ChEMBL_211948
Residue:
1249
Sequence:
MATAATEEPFPFHGLLPKKETGASSFLCRYPEYDGRGVLIAVLDTGVDPGAPGMQVTTDGKPKIIDIIDTTGSGDVNTATEVEPKDGEITGLSGRVLKIPANWTNPSGKYHIGIKNGYDFYPKALKERIQKERKEKIWDPIHRVALAEACRKQEEFDIANNGSSQANKLIKEELQSQVELLNSFEKKYSDPGPVYDCLVWHDGETWRACVDSNENGDLGKSTVLRNYKEAQEYGSFGTAEMLNYSVNIYDDGNLLSIVTSGGAHGTHVASIAAGHFPEEPERNGVAPGAQILSIKIGDTRLSTMETGTGLIRAMIEVINHKCDLVNYSYGEATHWPNSGRICEVINEAVWKHNTIYVSSAGNNGPCLSTVGCPGGTTSSVIGVGAYVSPDMMVAEYSLREKLPANQYTWSSRGPSADGALGVSISAPGGAIASVPNWTLRGTQLMNGTSMSSPNACGGIALVLSGLKANNVDYTVHSVRRALENTAIKADNIEVFAQGHGIIQVDKAYDYLIQNTSFANRLGFTVTVGNNRGIYLRDPVQVAAPSDHGVGIEPVFPENTENSEKISFQLHLALTSNSSWVQCPSHLELMNQCRHINIRVDPRGLREGLHYTEVCGYDIASPNAGPLFRVPITAVIAAKVNESSHYDLAFTDVHFKPGQIRRHFVEVPEGATWAEVTVCSCSSEVSAKFVLHAVQLVKQRAYRSHEFYKFCSLPEKGTLIEAFPVLGGKAIEFCIARWWASLSDVNIDYTISFHGIVCTAPQLNIHASEGINRFDVQSSLKYEDLAPCITLKSWVQTLRPVNAKTRPLGSRDVLPNNRQLYEMVLTYSFHQPKSGEVTPSCPLLCELLYESEFDSQLWIIFDQNKRQMGSGDAYPHQYSLKLEKGDYTIRLQIRHEQISDLDRLKDLPFIVSHRLSNTLSLDIHENHSLALLGKKKSSSLTLPPKYNQPFFVTSLPDDKIPKGAGPGCYLAGSLTLSKTELGKKADVIPVHYYLIPPPTKTKNGSKDKEKDSEKEKDLKEEFTEALRDLKIQWMTKLDSTDIYNELKETYPAYLPLYVARLHQLDAEKERMKRLNEIVDAANAVISHIDQTALAVYIAMKTDPRPDAATIKNDMDKQKSTLVDALCRKGCALADHLLHAQPHDGAAAGDAEAKEEEGESTLESLSETYWETTKWTDLFDTKVLTFAYKHALVNKMYGRGLKFATKLVEEKPTKENWKNCIQLMKLLGWTHCASFTENWLPIMYPPDYCVF
  
Inhibitor
Name:
BDBM50136651
Synonyms:
({2-[(S)-1-(2-Amino-acetyl)-2,3-dihydro-1H-indol-2-yl]-5-propyl-1H-imidazole-4-carbonyl}-amino)-acetic acid methyl ester | CHEMBL344879
Type:
Small organic molecule
Emp. Form.:
C20H25N5O4
Mol. Mass.:
399.4436
SMILES:
CCCc1nc([nH]c1C(=O)NCC(=O)OC)[C@@H]1Cc2ccccc2N1C(=O)CN
Structure:
Search PDB for entries with ligand similarity: