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Target
Serine protease 1
Ligand
BDBM50138657
Substrate
n/a
Meas. Tech.
ChEMBL_212906 (CHEMBL819934)
Ki
1320±n/a nM
Citation
 Wendt, MD; Rockway, TW; Geyer, A; McClellan, W; Weitzberg, M; Zhao, X; Mantei, R; Nienaber, VL; Stewart, K; Klinghofer, V; Giranda, VL Identification of novel binding interactions in the development of potent, selective 2-naphthamidine inhibitors of urokinase. Synthesis, structural analysis, and SAR of N-phenyl amide 6-substitution. J Med Chem 47:303-24 (2004) [PubMed]  Article 
Target
Name:
Serine protease 1
Synonyms:
Alpha-trypsin chain 1 | Alpha-trypsin chain 2 | Beta-trypsin | Cationic trypsinogen | PRSS1 | Serine protease 1 | TRP1 | TRY1 | TRY1_HUMAN | TRYP1 | Thrombin & trypsin | Trypsin | Trypsin I | Trypsin-1
Type:
Enzyme
Mol. Mass.:
26557.80
Organism:
Homo sapiens (Human)
Description:
P07477
Residue:
247
Sequence:
MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVSAGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVINARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIKNTIAANS
  
Inhibitor
Name:
BDBM50138657
Synonyms:
6-Carbamimidoyl-naphthalene-2-carboxylic acid (4-ethyl-phenyl)-amide | CHEMBL111660
Type:
Small organic molecule
Emp. Form.:
C20H19N3O
Mol. Mass.:
317.3844
SMILES:
CCc1ccc(NC(=O)c2ccc3cc(ccc3c2)C(N)=N)cc1
Structure:
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