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Target
Metabotropic glutamate receptor 8
Ligand
BDBM50034504
Substrate
n/a
Meas. Tech.
ChEMBL_104624 (CHEMBL872629)
EC50
400±n/a nM
Citation
 Collado, I; Pedregal, C; Bueno, AB; Marcos, A; González, R; Blanco-Urgoiti, J; Pérez-Castells, J; Schoepp, DD; Wright, RA; Johnson, BG; Kingston, AE; Moher, ED; Hoard, DW; Griffey, KI; Tizzano, JP (2S,1'S,2'R,3'R)-2-(2'-Carboxy-3'-hydroxymethylcyclopropyl) glycine is a highly potent group 2 and 3 metabotropic glutamate receptor agonist with oral activity. J Med Chem 47:456-66 (2004) [PubMed]  Article 
Target
Name:
Metabotropic glutamate receptor 8
Synonyms:
GRM8_RAT | Gprc1h | Grm8 | Metabotropic glutamate receptor | Metabotropic glutamate receptor 8 (mGlu8) | Mglur8 | glutamate receptor, metabotropic 8 precursor | mGlu8 | metabotropic glutamate 8
Type:
Enzyme
Mol. Mass.:
101886.18
Organism:
Rattus norvegicus (Rat)
Description:
P70579
Residue:
908
Sequence:
MVCEGKRLASCPCFFLLTAKFYWILTMMQRTHSQEYAHSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKERCPGYIGLCPRMVTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQINNKSTEYKIIGHWTNQLHLKVEDMQWANREHTHPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNINRTGCQRIPIIKLEWHSPWAVVPVFIAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRIFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPHTIIDYGEQRTLDPENARGVLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKRKRSFKAVVTAATMQSKLIQKGNDRPNGEVKSELCESLETNTSSTKTTYISYSNHSI
  
Inhibitor
Name:
BDBM50034504
Synonyms:
(1S,2S)-2-((S)-Amino-carboxy-methyl)-cyclopropanecarboxylic acid | 2-(Amino-carboxy-methyl)-cyclopropanecarboxylic acid | 2-(Amino-carboxy-methyl)-cyclopropanecarboxylic acid(2S,3S,4S-CCG) | CHEMBL280563 | L-CCGI
Type:
Small organic molecule
Emp. Form.:
C6H9NO4
Mol. Mass.:
159.14
SMILES:
N[C@@H]([C@H]1C[C@@H]1C(O)=O)C(O)=O
Structure:
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