Reaction Details Report a problem with these data
Target
Type-2 angiotensin II receptor
Ligand
BDBM50141058
Substrate
n/a
Meas. Tech.
ChEMBL_35278 (CHEMBL648317)
Ki
>10000±n/a nM
Citation
 Wan, Y; Wallinder, C; Johansson, B; Holm, M; Mahalingam, AK; Wu, X; Botros, M; Karlén, A; Pettersson, A; Nyberg, F; Fändriks, L; Hallberg, A; Alterman, M First reported nonpeptide AT1 receptor agonist (L-162,313) acts as an AT2 receptor agonist in vivo. J Med Chem 47:1536-46 (2004) [PubMed]  Article 
Target
Name:
Type-2 angiotensin II receptor
Synonyms:
AGTR2 | AGTR2_HUMAN | AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Angiotensin II, central | Type-2 angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41201.61
Organism:
Homo sapiens (Human)
Description:
Angiotensin II, central 0 0::P50052
Residue:
363
Sequence:
MKGNSTLATTSKNITSGLHFGLVNISGNNESTLNCSQKPSDKHLDAIPILYYIIFVIGFLVNIVVVTLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYIVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMGVINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRESMSCRKSSSLREMETFVS
  
Inhibitor
Name:
BDBM50141058
Synonyms:
CHEMBL291089 | N-Hexyloxycarbonyl-3-[4-(2-ethyl-5,7-dimethylimidazo-[4,5-b]pyridin-3-ylmethyl)phenyl]-5-isobutylthiophene-2-sulfonamide
Type:
Small organic molecule
Emp. Form.:
C32H42N4O4S2
Mol. Mass.:
610.83
SMILES:
CCCCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc23)cc1
Structure:
Search PDB for entries with ligand similarity: