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Target
Tumor necrosis factor receptor superfamily member 1A
Ligand
BDBM50141526
Substrate
n/a
Meas. Tech.
ChEBML_224214
IC50
2000±n/a nM
Citation
 Meng, CQ; Zheng, XS; Ni, L; Ye, Z; Simpson, JE; Worsencroft, KJ; Hotema, MR; Weingarten, MD; Skudlarek, JW; Gilmore, JM; Hoong, LK; Hill, RR; Marino, EM; Suen, KL; Kunsch, C; Wasserman, MA; Sikorski, JA Discovery of novel heteroaryl-substituted chalcones as inhibitors of TNF-alpha-induced VCAM-1 expression. Bioorg Med Chem Lett 14:1513-7 (2004) [PubMed]  Article 
Target
Name:
Tumor necrosis factor receptor superfamily member 1A
Synonyms:
CD_antigen=CD120a | TBPI | TNF-R1 | TNF-RI | TNFAR | TNFR-I | TNFR1 | TNFRSF1A | TNR1A_HUMAN | Tumor necrosis factor receptor R1 | Tumor necrosis factor receptor superfamily member 1A | Tumor necrosis factor receptor superfamily member 1A, membrane form | Tumor necrosis factor-binding protein 1 | p55 | p60
Type:
PROTEIN
Mol. Mass.:
50495.39
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1509419
Residue:
455
Sequence:
MGLSTVPDLLLPLVLLELLVGIYPSGVIGLVPHLGDREKRDSVCPQGKYIHPQNNSICCTKCHKGTYLYNDCPGPGQDTDCRECESGSFTASENHLRHCLSCSKCRKEMGQVEISSCTVDRDTVCGCRKNQYRHYWSENLFQCFNCSLCLNGTVHLSCQEKQNTVCTCHAGFFLRENECVSCSNCKKSLECTKLCLPQIENVKGTEDSGTTVLLPLVIFFGLCLLSLLFIGLMYRYQRWKSKLYSIVCGKSTPEKEGELEGTTTKPLAPNPSFSPTPGFTPTLGFSPVPSSTFTSSSTYTPGDCPNFAAPRREVAPPYQGADPILATALASDPIPNPLQKWEDSAHKPQSLDTDDPATLYAVVENVPPLRWKEFVRRLGLSDHEIDRLELQNGRCLREAQYSMLATWRRRTPRREATLELLGRVLRDMDLLGCLEDIEEALCGPAALPPAPSLLR
  
Inhibitor
Name:
BDBM50141526
Synonyms:
(E)-3-[2-Methoxy-5-(5-methyl-thiophen-2-yl)-phenyl]-1-(3,4,5-trimethoxy-phenyl)-propenone | CHEMBL36771
Type:
Small organic molecule
Emp. Form.:
C24H24O5S
Mol. Mass.:
424.509
SMILES:
COc1ccc(cc1\C=C\C(=O)c1cc(OC)c(OC)c(OC)c1)-c1ccc(C)s1
Structure:
Search PDB for entries with ligand similarity: