Reaction Details Report a problem with these data
Target
Prostaglandin E2 receptor EP4 subtype
Ligand
BDBM50142476
Substrate
n/a
Meas. Tech.
ChEMBL_158452 (CHEMBL763256)
EC50
0.800000±n/a nM
Citation
Elworthy, TR; Kertesz, DJ; Kim, W; Roepel, MG; Quattrocchio-Setti, L; Smith, DB; Tracy, JL; Chow, A; Li, F; Brill, ER; Lach, LK; McGee, D; Yang, DS; Chiou, SS Lactams as EP4 prostanoid receptor subtype selective agonists. Part 1: 2-Pyrrolidinones-stereochemical and lower side-chain optimization. Bioorg Med Chem Lett 14:1655-9 (2004) [PubMed] Article
More Info.:
Target
Name:
Prostaglandin E2 receptor EP4 subtype
Synonyms:
PE2R4_HUMAN | PGE receptor EP4 subtype | PGE2 receptor EP4 subtype | PTGER2 | PTGER4 | Prostaglandin E2 receptor | Prostanoid EP4 receptor
Type:
Enzyme
Mol. Mass.:
53134.53
Organism:
Homo sapiens (Human)
Description:
P35408
Residue:
488
Sequence:
MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTAHAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRGHPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQPSLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSGQHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPGMGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSETLNLSEKCI
Inhibitor
Name:
BDBM50142476
Synonyms:
7-{(R)-2-[(E)-3-(4'-Chloro-2'-methyl-biphenyl-3-yl)-3-hydroxy-propenyl]-5-oxo-pyrrolidin-1-yl}-heptanoic acid | CHEMBL298026
Type:
Small organic molecule
Emp. Form.:
C27H32ClNO4
Mol. Mass.:
470
SMILES:
Cc1cc(Cl)ccc1-c1cccc(c1)C(O)\C=C\[C@H]1CCC(=O)N1CCCCCCC(O)=O