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Target
Follicle-stimulating hormone receptor
Ligand
BDBM50142658
Substrate
n/a
Meas. Tech.
ChEBML_69355
EC50
1200±n/a nM
Citation
 Guo, T; Adang, AE; Dong, G; Fitzpatrick, D; Geng, P; Ho, KK; Jibilian, CH; Kultgen, SG; Liu, R; McDonald, E; Saionz, KW; Valenzano, KJ; van Straten, NC; Xie, D; Webb, ML Small molecule biaryl FSH receptor agonists. Part 2: Lead optimization via parallel synthesis. Bioorg Med Chem Lett 14:1717-20 (2004) [PubMed]  Article 
Target
Name:
Follicle-stimulating hormone receptor
Synonyms:
FSH-R | FSHR | FSHR_HUMAN | Follicle stimulating hormone receptor | Follicle-stimulating hormone receptor | Follitropin receptor | LGR1
Type:
PROTEIN
Mol. Mass.:
78273.21
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1351769
Residue:
695
Sequence:
MALLLVSLLAFLSLGSGCHHRICHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPDVHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNGTQLDELNLSDNNNLEELPNDVFHGASGPVILDISRTRIHSLPSYGLENLKKLRARSTYNLKKLPTLEKLVALMEASLTYPSHCCAFANWRRQISELHPICNKSILRQEVDYMTQARGQRSSLAEDNESSYSRGFDMTYTEFDYDLCNEVVDVTCSPKPDAFNPCEDIMGYNILRVLIWFISILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLDCKVQLRHAASVMVMGWIFAFAAALFPIFGISSYMKVSICLPMDIDSPLSQLYVMSLLVLNVLAFVVICGCYIHIYLTVRNPNIVSSSSDTRIAKRMAMLIFTDFLCMAPISFFAISASLKVPLITVSKAKILLVLFHPINSCANPFLYAIFTKNFRRDFFILLSKCGCYEMQAQIYRTETSSTVHNTHPRNGHCSSAPRVTNGSTYILVPLSHLAQN
  
Inhibitor
Name:
BDBM50142658
Synonyms:
(S)-3-(4'-Methoxy-3',5'-dimethyl-biphenyl-4-ylmethyl)-4-methyl-1-octyl-piperazine-2,5-dione | CHEMBL417003
Type:
Small organic molecule
Emp. Form.:
C29H40N2O3
Mol. Mass.:
464.6395
SMILES:
CCCCCCCCN1CC(=O)N(C)[C@@H](Cc2ccc(cc2)-c2cc(C)c(OC)c(C)c2)C1=O
Structure:
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