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Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50081148
Substrate
n/a
Meas. Tech.
ChEMBL_71739 (CHEMBL680262)
IC50
10±n/a nM
Citation
 Jiang, J; DeVita, RJ; Goulet, MT; Wyvratt, MJ; Lo, JL; Ren, N; Yudkovitz, JB; Cui, J; Yang, YT; Cheng, K; Rohrer, SP Syntheses and structure-activity relationship studies of piperidine-substituted quinolones as nonpeptide gonadotropin releasing hormone antagonists. Bioorg Med Chem Lett 14:1795-8 (2004) [PubMed]  Article 
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR_RAT | GnRH receptor | GnRH-R | Gnrhr
Type:
PROTEIN
Mol. Mass.:
37767.60
Organism:
Rattus norvegicus
Description:
ChEMBL_1335047
Residue:
327
Sequence:
MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL
  
Inhibitor
Name:
BDBM50081148
Synonyms:
7-Chloro-3-(3,5-dimethyl-phenyl)-6-nitro-4-((S)-2-piperidin-2-yl-ethoxy)-1H-quinolin-2-one | CHEMBL294910 | CHEMBL90725
Type:
Small organic molecule
Emp. Form.:
C24H26ClN3O4
Mol. Mass.:
455.934
SMILES:
Cc1cc(C)cc(c1)-c1c(OCCC2CCCCN2)c2cc(c(Cl)cc2[n-]c1=[OH+])[N+]([O-])=O
Structure:
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