Reaction Details Report a problem with these data
Target
Legumain
Ligand
BDBM50143614
Substrate
n/a
Meas. Tech.
ChEMBL_96917 (CHEMBL707896)
IC50
38±n/a nM
Citation
Ekici, OD; Götz, MG; James, KE; Li, ZZ; Rukamp, BJ; Asgian, JL; Caffrey, CR; Hansell, E; Dvorák, J; McKerrow, JH; Potempa, J; Travis, J; Mikolajczyk, J; Salvesen, GS; Powers, JC Aza-peptide Michael acceptors: a new class of inhibitors specific for caspases and other clan CD cysteine proteases. J Med Chem 47:1889-92 (2004) [PubMed] Article
More Info.:
Target
Name:
Legumain
Synonyms:
3.4.22.34 | Asparaginyl endopeptidase | LGMN | LGMN_HUMAN | PRSC1 | Protease, cysteine 1
Type:
n/a
Mol. Mass.:
49411.12
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
433
Sequence:
MVWKVAVFLSVALGIGAVPIDDPEDGGKHWVVIVAGSNGWYNYRHQADACHAYQIIHRNGIPDEQIVVMMYDDIAYSEDNPTPGIVINRPNGTDVYQGVPKDYTGEDVTPQNFLAVLRGDAEAVKGIGSGKVLKSGPQDHVFIYFTDHGSTGILVFPNEDLHVKDLNETIHYMYKHKMYRKMVFYIEACESGSMMNHLPDNINVYATTAANPRESSYACYYDEKRSTYLGDWYSVNWMEDSDVEDLTKETLHKQYHLVKSHTNTSHVMQYGNKTISTMKVMQFQGMKRKASSPVPLPPVTHLDLTPSPDVPLTIMKRKLMNTNDLEESRQLTEEIQRHLDARHLIEKSVRKIVSLLAASEAEVEQLLSERAPLTGHSCYPEALLHFRTHCFNWHSPTYEYALRHLYVLVNLCEKPYPLHRIKLSMDHVCLGHY
Inhibitor
Name:
BDBM50143614
Synonyms:
(E)-3-{(S)-N'-[(S)-2-((S)-2-Benzyloxycarbonylamino-propionylamino)-propionyl]-N-carbamoylmethyl-hydrazinocarbonyloxy}-acrylic acid benzyl ester | CHEMBL292589
Type:
Small organic molecule
Emp. Form.:
C27H31N5O9
Mol. Mass.:
569.5631
SMILES:
C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](C)C(=O)NN(CC(N)=O)C(=O)O\C=C\C(=O)OCc1ccccc1