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Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50143716
Substrate
n/a
Meas. Tech.
ChEMBL_924 (CHEMBL615772)
Ki
>1000±n/a nM
Citation
 Leonardi, A; Barlocco, D; Montesano, F; Cignarella, G; Motta, G; Testa, R; Poggesi, E; Seeber, M; De Benedetti, PG; Fanelli, F Synthesis, screening, and molecular modeling of new potent and selective antagonists at the alpha 1d adrenergic receptor. J Med Chem 47:1900-18 (2004) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1A | 5-hydroxytryptamine receptor 1A (5-HT-1A) | 5HT1A_HUMAN | ADRB2RL1 | ADRBRL1 | Dopamine D2 receptor and serotonin 1a receptor | G-21 | HTR1A | Serotonin receptor 1A
Type:
n/a
Mol. Mass.:
46122.49
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
422
Sequence:
MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRQ
  
Inhibitor
Name:
BDBM50143716
Synonyms:
7-{2-[4-(2,5-Dichloro-phenyl)-piperazin-1-yl]-ethyl}-7-aza-spiro[3.5]nonane-6,8-dione | CHEMBL55882
Type:
Small organic molecule
Emp. Form.:
C20H25Cl2N3O2
Mol. Mass.:
410.337
SMILES:
Clc1ccc(Cl)c(c1)N1CCN(CCN2C(=O)CC3(CCC3)CC2=O)CC1
Structure:
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