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Target
Alpha-1A adrenergic receptor
Ligand
BDBM50143704
Substrate
n/a
Meas. Tech.
ChEMBL_34031 (CHEMBL646170)
Ki
786.3±n/a nM
Citation
 Leonardi, A; Barlocco, D; Montesano, F; Cignarella, G; Motta, G; Testa, R; Poggesi, E; Seeber, M; De Benedetti, PG; Fanelli, F Synthesis, screening, and molecular modeling of new potent and selective antagonists at the alpha 1d adrenergic receptor. J Med Chem 47:1900-18 (2004) [PubMed]  Article 
Target
Name:
Alpha-1A adrenergic receptor
Synonyms:
ADA1A_RAT | Adra1a | Adra1c | Alpha-1 adrenoreceptor | Alpha-1A adrenoceptor | Alpha-1A adrenoreceptor | Alpha-1C adrenergic receptor | adrenergic Alpha1A
Type:
Protein
Mol. Mass.:
51620.15
Organism:
Rattus norvegicus (Rat)
Description:
P43140
Residue:
466
Sequence:
MVLLSENASEGSNCTHPPAPVNISKAILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWVLSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYVPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNVPAEGGGVSSAKNKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLRRRQSSKHALGYTLHPPSQALEGQHRDMVRIPVGSGETFYKISKTDGVCEWKFFSSMPQGSARITVPKDQSACTTARVRSKSFLQVCCCVGSSAPRPEENHQVPTIKIHTISLGENGEEV
  
Inhibitor
Name:
BDBM50143704
Synonyms:
8-[2-({2-[(2,5-Dichloro-phenyl)-methyl-amino]-ethyl}-methyl-amino)-ethyl]-8-aza-spiro[4.5]decane-7,9-dione | CHEMBL55790
Type:
Small organic molecule
Emp. Form.:
C21H29Cl2N3O2
Mol. Mass.:
426.38
SMILES:
CN(CCN(C)c1cc(Cl)ccc1Cl)CCN1C(=O)CC2(CCCC2)CC1=O
Structure:
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